GH1 and obesity due to melanocortin 4 receptor deficiency: Ize-Ludlow et al. proposed criteria for the diagnosis of ROHHAD syndrome when naming the condition in 2007, which included the presence of alveolar hypoventilation after the age of 2 years and evidence of hypothalamic dysfunction as defined by more than one of the following: rapid-onset obesity, hyperprolactinaemia, central hypothyroidism, disordered water balance, failed growth hormone stimulation, corticotropin deficiency, or delayed/precocious puberty [4].