AQP4 and chronic kidney disease: In the CKD group, AQP4-positive immunoreactivity in astrocytes and blood vessels was markedly elevated in the CA1 and molecular layer of the DG region compared with the control group (CA1, F1,9 = 18.77, p < 0.001; DG, F1,9 = 25.57, p < 0.001; Figure 8(A3–B4,A7–B8),E,F).