In a prospective study (n = 922, ≥65 y, 65% F), although low IGFBP-1 was associated with increased prevalence of glucose intolerance, low IGF-I and IGFBP-3 levels, and not IGFBP-1, were associated with increased IL-6 and CRP [115]. This evidence concerns the gene IGFBP1 and Glucose intolerance.