Hsa_circ_0031891 promotes PDGF-BB-induced human aortic VSMCs proliferation, migration, and dedifferentiation partly via regulating the miR579-3p/high-mobility group box 1 (HMGB1) axis, suggesting a potential therapeutic strategy for atherosclerosis (Figure 5c) [175]. The gene discussed is HMGB1; the disease is atherosclerosis.