AKT1 and asthma: LncRNA RP5-857K21.7 is downregulated in PDGF-BB-induced airway SMCs, and its overexpression suppresses the PI3K/AKT/mTOR pathway through sponging miR508-3, significantly inhibiting PDGF-BB-induced cell proliferation and migration and inducing cell apoptosis, providing a new target for the treatment of asthma (Figure 4d) [155].