CDK1 and atherosclerosis: Notably, miR378a-5p negatively regulates the expression of cyclin-dependent kinase 1 (CDK1) and its downstream molecule p21 after PDGF-BB stimulation to promote VSMC proliferation, suggesting a novel therapeutic strategy via targeting miR378a-5p in the prevention of PDGF-BB-stimulated atherosclerosis and stent restenosis (Figure 2c) [49].