Given PDGFs have been demonstrated to regulate vascular cells in recent years, and, particularly, microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) are involved in the regulation of PDGF/PDGFR signaling pathways through competitive interactions, it is interesting to conclude the recent findings in this field, providing potential mechanisms of action of vascular remodeling and therapeutic strategies for the treatment of vascular-dysfunction-related diseases, particularly CVDs and respiratory diseases. This evidence concerns the gene PDGFRB and respiratory system disorder.