Several iron-related genes, such as scavenger receptor class A member 5 (SCARA5), erythroferrone (ERFE), lipocalin 2, TfR2, SLC11A1, and cytochrome B reductase 1 (CYBRD1), were found to be dysregulated in different cancers, likely due to abnormal DNA methylation [99]. The gene discussed is CYBRD1; the disease is cancer.