In T- and B-acute lymphoblastic leukemia cell lines and patient samples, hypermethylation of the ferroptosis suppressor protein 1 (Fsp1) gene promoter prevents Nrf2 from binding and suppresses the expression of FSP1, a key enzyme involved in preventing lipid peroxidation, thereby promoting ferroptosis [105,106]. This evidence concerns the gene AIFM2 and acute lymphoblastic leukemia.