Moreover, Ma et al. demonstrated that neratinib induces ferroptosis in acute myeloid leukemia (AML) cells, as evidenced by increased ROS levels, elevated MDA content, enhanced cellular Fe2+ activity, and downregulation of GPX4 and FTH1 expression, along with upregulation of ACSL4 expression. This evidence concerns the gene ACSL4 and acute myeloid leukemia.