Regular fasting-mimicking diets can act on the tumor microenvironment and increase the efficacy of immunotherapies (anti-PD-L1 and anti-OX40) in poorly immunogenic TNBCs by expanding the early depletion of effector T-cells, switching cancer metabolism from glycolysis to the respiratory system, and reducing collagen deposition. This evidence concerns the gene TNFRSF4 and neoplasm.