Here, we report a CRISPR/Cas9-mediated approach for a heterozygous dominant p.Gly275_Lys280del in-frame variant mapped in exon 9 of the COL6A1 gene in the UCMD patient who never achieved the ability to stand and walk. This evidence concerns the gene COL6A1 and Congenital muscular dystrophy, Ullrich type.