CD163 and infection: Whitworth et al. employed the CRISPR/Cas9 system to create CD163 knockout pigs and tested these animals’ susceptibility to the PRRSV, demonstrating that these gene-edited pigs did not exhibit signs of infection, viremia, or associated pathology, which indicated that CD163 gene editing offers a viable strategy to enhance resistance to PRRS in swine, potentially reducing significant economic losses in the swine industry [7].