Adenosine monophosphate (AMP) is primarily generated by non-cardiomyocytes in MI and accumulated by fibroblasts because it cannot be further cleaved to adenosine, a process canonically undertaken by neighboring T cells whose adenosine overproduction triggers IL6 expression by cardiac fibroblasts, triggering an inflammatory cascade [57]. The gene discussed is IL6; the disease is myocardial infarction.