In parallel, inhibition of the suppressor of cytokine signaling 1 (encoded by Socs1) is another consequence of the miR-155 containing exosome uptake, resulting in augmented post-MI inflammation (and cardiac rupture) because of induced expression of proinflammatory cytokines (IL1β, TNFα, IL6, MCP1) which are canonically inhibited by SOCS1 [125]. Here, CCL2 is linked to myocardial infarction.