Similarly, YAP, which is being up-regulated in cardiac fibroblasts upon MI or neuroendocrine stimulation injury, binds at TEAD recognition sites to myocardin-related transcription factor A (MRTF-A) to induce fibroblast trans-differentiation into myofibroblasts, a process crucial for fibrosis development. The gene discussed is MRTFA; the disease is myocardial infarction.