In studies of adenomyosis, low expression of histone deacetylase 3 (HDAC3) has been negatively correlated with the degree of fibrosis, and reduced HDAC3 expression disrupts the NF-κB pathway, impairing the resolution of inflammation and endometrium repair and ultimately exacerbating the disease [59]. This evidence concerns the gene NFKB1 and adenomyosis.