PTGS2 and adenomyosis: Notably, Wnt/β-catenin signaling is altered in mouse models of adenomyosis [14], and COX-2 expression is positively correlated with β-catenin levels in the endometrium of adenomyosis, suggesting that COX-2 may be involved in the pathogenesis of adenomyosis through the Wnt/β-catenin signaling pathway [15].