DNMT1 and colorectal cancer: In a study using the HCT116 colorectal cancer cell line, the disruption of DNMT1 and DNMT3B, as well as pharmacological inhibition with 5-Aza-2s-deoxycytidine (5-Aza-dC, decitabine), resulted in the demethylation of MEG3-DMR and the expression of 14q32 miRNAs, leading to the suppression of adhesion, invasion, and migration (AIM) properties in metastatic tumor cells [27].