PGD and Stroke: Additionally, we identified a group of hub genes, namely PRDX1, ACTB (actin beta), APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein), CYFIP1 (cytoplasmic FMR1 interacting protein 1), and PGD (hosphogluconate dehydrogenase), which exhibited high expression in stroke and significant downregulation of gene expression under IPostC.