The target genes of Runx2—vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), BSP, OPN, and matrix metalloproteinases (MMPs)—promote the differentiation, migration, and invasion of endothelial cells during angiogenesis [112], which is crucial for tumor growth and metastasis. The gene discussed is RUNX2; the disease is neoplasm.