Indeed, numerous studies have suggested that WFS1 exerts effects that extend beyond WS1 [5], a rare neurodegenerative disorder characterized by diabetes insipidus DI, diabetes mellitus DM, optic atrophy OA, and deafness D (DIDMOAD), as well as by additional issues such as urinary system abnormalities and disruptions in the endocrine system [7,8,9]. The gene discussed is WFS1; the disease is Wolfram syndrome.