Moreover, Han and colleagues identified α-mangostin (0.62, 1.25, and 2.50 μM) as a potent inhibitor of lysine-specific demethylase 1 (LSD1), a histone demethylase enzyme, and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression in breast cancer cells, suggesting a novel avenue for LSD1 inhibitor research [18]. The gene discussed is KDM1A; the disease is breast cancer.