α-Mangostin (10 μM) induced cell cycle arrest and decreased the expression of HPV16 oncogenes (E6 and E7) and potassium voltage-gated channel subfamily H member 1 (KCNH1), whose overexpression was found to be associated with osteosarcoma pathogenesis in xenografted SiHa cells. This evidence concerns the gene KCNH1 and osteosarcoma.