Exosomes from SKOV-3 and TOV-21G ovarian cancer cells increased the expression of mouse double minute 2 homolog (MDM2) and interleukin 18 (IL-18) in fibroblasts but were reduced after α-mangostin (12.5 and 29.98 μM) treatment on gene expression in fibroblasts [67]. The gene discussed is IL18; the disease is ovarian carcinoma.