PPARA and colorectal carcinoma: To further examine the cellular processes implicated in GO:CC regulation, we observed that non-responder CRC patients presented some related KEGG pathways with negative NESs (p-value < 0.05, FDR < 0.05), such as spliceosome, oxidative phosphorylation, ribosome biogenesis in eukaryotes, peroxisome, thermogenesis, and the PPAR signaling pathway (Figure 1B).