Type 2 cytokines such as IL-4, IL-5, and IL-13 (i.e., the targets of the newly approved monoclonal antibodies for uncontrolled severe and refractory CRSwNP) are derived not only from eosinophils but also from other cellular subsets, including innate lymphoid cells 2 (ILC2), basophils, and MCs [5]. Here, IL4 is linked to chronic rhinosinusitis with nasal polyps.