Similarly, Panobinostat, a hydroxamic acid-derived pan-HDACi, reduces vessel density in GBM mouse subcutaneous xenografts and potently limits angiogenesis by disrupting HDAC6/Hsp90 interaction, promoting hypoxia-inducible factor (HIF) 1α instability and a consequent decrease in VEGF expression [185]. This evidence concerns the gene HDAC6 and glioblastoma.