CTRC and chronic pancreatitis: Mutations in genes, such as cystic fibrosis transmembrane conductance regulator (CFTR), protease serine 1/cationic trypsinogen (PRSS1), chymotrypsin C (CTRC), and serine protease inhibitor Kazal type 1 (SPINK1), which are involved in trypsinogen activation and regulation, have been associated with recurrent acute pancreatitis and its evolution to chronic pancreatitis [12].