According to the bioinformatic resources Cerebrovascular Disease Knowledge Portal (CDKP) and Cardiovascular Disease Knowledge Portal (CVDKP), which combine and analyze the results of genetic associations of the largest consortiums for the study of cardio- and cerebrovascular diseases, the IS-related C11orf58 SNPs are associated with different types of stroke (lacunar stroke, TOAST small artery occlusion, large artery atherosclerosis major) and a number of stroke-related phenotypes, like blood pressure, total cholesterol, LDL cholesterol, serum ApoB, and atrial fibrillation (Table S19). The gene discussed is APOB; the disease is Stroke.