Additionally, information gathered through the bioinformatic resource, the Cardiovascular Disease Knowledge Portal, revealed that the risk alleles of IS-associated SNPs were associated with reduced levels of LDL cholesterol (rs10766342, rs11024032, rs11826990, rs3203295) and total cholesterol (rs10766342, rs11024030, rs11024032, rs11826990, rs3203295, rs10832676, rs4757429), suggesting the potential involvement of polymorphic variants in C11orf58 in the development of atherosclerosis and thrombosis, the major causes of IS. The gene discussed is C11orf58; the disease is cardiovascular disorder.