From pathophysiologic points, GDM and hypertensive disorders of pregnancy share similar abnormalities, like insulin resistance, central obesity, dyslipidemia, oxidative stress, endothelial dysfunction, chronic inflammation (neutrophil activation, abnormal cytokines), and abnormal levels of adipokines (low levels of adiponectin, high levels of leptin) [61]. The gene discussed is LEP; the disease is gestational diabetes.