The hypothesis that NCC activation is a mechanism of CNI-induced hypertension could have a therapeutic consequence: CNI induced hypertension could be especially sensitive to thiazide diuretics, and seminal animal and human studies suggest this opportunity, even if studies clearly demonstrating the superiority of thiazides over other antihypertensive treatment in those patients are not yet available [163]. The gene discussed is SLC12A3; the disease is hypertensive disorder.