A lower NCC activity results in a reduction of the extracellular fluid volume driven by an increase in Na+, K+, Mg2+, and H+ renal wasting, which causes hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and hyperreninemic hyperaldosteronism with associated hypotension [86]. Here, SLC12A3 is linked to Hypokalemia.