AKT1 and familial avascular necrosis of femoral head: At present, although there is no direct evidence to show whether the disruption of EC metabolism plays a key role in the occurrence of ANFH, transcriptome studies on the local bone tissue of patients with ANFH showed that the differentially expressed genes (DEGs) between the control group and the necrosis group mainly influenced the PI3K-Akt pathway, and were mainly involved in the glycolysis/gluconeogenesis pathway [117].