As mentioned before, BMP is often used in combination with other angiogenic factors to treat ANFH, such as VEGF [64,65], [99,100,101], HIF-1α [92], COMP-Ang1 [97], and basic fibroblast growth factor (bFGF) [102], which have all been reported in combination with BMP. This evidence concerns the gene HIF1A and familial avascular necrosis of femoral head.