CH25H and acute promyelocytic leukemia: For example, 50 μM of 25HC induced IL-8 secretion in U937 human promyelocytic leukemia of neuronal cells; however, 0.1 μM of 25HC decreased LPS-induced IL-1β mRNA and protein and inflammasome activation in cholesterol-25-hydroxylase-defficient bone-marrow-derived monocytes.