NFE2L2 and leishmaniasis: In addition to modulating Nrf2 in leishmaniasis, these compounds also directly promote an apoptosis-like process in the promastigote and amastigote forms of L. amazonensis, which results in a decrease in ROS, nitric oxide, TGF-β, and IL-10, followed by an increase in Nrf2/HO-1/Ferritin expression, which modulates the parasites’ intracellular proliferation [56,58].