For instance, Glutathione S-transferases (GSTP1) implicating carcinogen defenses [59], growth-factor-signaling pathways (NKX3.1, PTEN) that regulate the growth and survival of prostate cells [60], and AR, which is a transcription factor, are critical determinants of prostate cancer phenotype cells [61]. Here, NKX3-1 is linked to Familial prostate cancer.