TLR4 and hidradenitis suppurativa: Although some studies have failed to demonstrate the involvement of variants in TLR4 in determining a certain susceptibility toward hidradenitis suppurativa [41], given the in silico prediction tool scores (CADD score 36) and the role of the TLR4-encoded protein, it is possible to hypothesize that p.(Arg731Ter) may act as a “minor factor” in the II-2G phenotype.