IDH1 and neoplasm: Several other genes involved in glucose metabolism and Isocytrate DeHydrogenase 1 (IDH1)-mutant glial cell proliferation have been reported to respond to glutamine deprivation, including the N-myc Downstream Regulated Gene 2 (NDRG2), a member of the N-myc downregulation pathway acting as a tumour suppressor in the absence of glutamine [63].