IFNG and neoplasm: Additionally, Chowdhury et al. (2022) found that CD8+ T cells stimulated by IL-12 resulted in an increase in intracellular acetyl CoA levels and they were able to sustain IFNγ production in a nutrient-depleted, tumor-conditioned media; therefore, CD8+ T cells may require higher concentrations of acetate for optimal function, which potentially result in an anti-tumor effect [95,96,97].