Among them, we can report the histopathological assessment of proliferation markers (Ki-67 and/or mitotic indices) that are used for staging the tumor as low-grade (G1, Ki-67 ≤ 2%), intermediate-grade (G2, Ki-67 3–20%), or high-grade (G3, Ki-67 > 20%), the extent of liver disease, the location of the primary tumor, and the presence of a functional syndrome [7,8,9]. Here, MKI67 is linked to neoplasm.