Oral Pg induced mild gut inflammation, significant loss of dopaminergic neurons, and microglial activation in SNpc in a PD mouse model.Pg ingestion triggered an immune response involving IL-17A and increased IL-17RA in dopaminergic neurons.Elevated LRRK2 expression accompanied Pg-induced neurodegeneration.The findings highlighted the role of Pg, IL-17A, and LRRK2 in dopaminergic neurodegeneration and neuroinflammation in LRRK2-associated PD. This evidence concerns the gene IL17RA and Parkinson disease.