To elucidate the global signaling network of Cbl proteins in NB, including its regulated proteins and PTMs, Pedersen et al. employed SILAC-based quantitative proteomics along with TMT-based phosphoproteomics to compare the protein alteration in Cbl/Cbl-b -depleted SH-SY5Y cells in response to various drug treatments [53]. Here, CBLB is linked to neuroblastoma.