IGHE and allergic disease: In IgE-mediated allergic reactions, IL-4, IL-5, and IL-13 produced by mast cells, basophils, dendritic cells, Th2 lymphocytes, and ILC2 directly stimulate B cells in the production of IgE, eosinophils in the secretion of IL-6, IL-8, IL-10, and IL-13, leukotrienes through granulocyte–macrophage colony-stimulating factors and eotaxins, and macrophages during differentiation in the M2 subtype [92,93].