The classical “atopic march” was based on population studies that have shown that the peak occurrence of food sensitization, food allergies, and atopic dermatitis was in the first 2 years of life, and it preceded that of aeroallergen-specific IgE responses, asthma, allergic rhinitis, and allergic conjunctivitis [12,19]. The gene discussed is IGHE; the disease is atopic eczema.