By analyzing the expression levels of glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and 4-Hydroxy-2-nonenal (4-HNE) in resected lung adenocarcinoma tissues, the study seeks to establish a relationship with clinicopathological factors and patient outcomes. This evidence concerns the gene AIFM2 and lung adenocarcinoma.