Gene mutations observed differ between lung adenocarcinoma and lung squamous cell carcinoma, with KRAS, EGFR, LPHN3, KEAP1, and TLR4 being relatively common in lung adenocarcinoma, whereas BAI3, FBXW7, GRM8, ERBB4, MUC16, and RUNX1T1 are common in lung squamous cell carcinoma [35]. This evidence concerns the gene ERBB4 and squamous cell lung carcinoma.