However, eHsp90 is primarily known for enhancing the invasiveness of cancer cells by interacting with ECM proteins and ECM-modifying proteins present in the TME, such as Matrix Metalloproteinase (MMP)-2, MMP9, Plasminogen, Collagen-1, Fibronectin (FN), and LOX-like protein-2 (LOXL2) [18,20,21,22,24,25,26,27,44,45,46]. This evidence concerns the gene MMP9 and cancer.