HSP90AA1 and metastatic malignant neoplasm: Similarly, various large population cohort studies for Multiple myeloma [109], Lung [110], Liver [111], Melanoma [112], Colorectal [113], Gastric [114,115], Hepatic [116], and Breast cancer [39] have consistently shown that plasma or serum Hsp90 is elevated in patients with invasive and metastatic cancers compared to healthy individuals and patients with benign tumors.