Similarly, various large population cohort studies for Multiple myeloma [109], Lung [110], Liver [111], Melanoma [112], Colorectal [113], Gastric [114,115], Hepatic [116], and Breast cancer [39] have consistently shown that plasma or serum Hsp90 is elevated in patients with invasive and metastatic cancers compared to healthy individuals and patients with benign tumors. Here, HSP90AA1 is linked to melanoma.