High rates of FDG-6-phosphatase activity, high expression of P-glycoprotein, and low GLUT1 and GLUT2 expression in moderately and well-differentiated HCC [8] result in low uptake of FDG into the HCC cell, rapid phosphorylation of FDG, and then efflux of FDG back out of the cell. Here, SLC2A2 is linked to hepatocellular carcinoma.