Tumor-associated macrophages (TAMs) are crucial infiltrating immune cells that interact with glial cells, accounting for 30–40% of the cellular components in GBM IDH-wt [24,25], and include microglia, perivascular macrophages, meningeal macrophages and macrophages of the circumventricular organ and choroid plexus. The gene discussed is IDH1; the disease is neoplasm.