The GBM IDH-wt TME exhibits a high level of intratumoral heterogeneity and is composed of a complex system of cells that display diverse functions in response to different stimuli, where lymphocyte and monocyte lineage cells are characterized by dynamic changes, having both effector and suppressive phenotypes and, at alternate moments, pro-and anti-tumor properties [12,13,14,15]. The gene discussed is IDH1; the disease is neoplasm.