RUNX1 and acute myeloid leukemia: Cases with recurrent genetic abnormalities, including t(8;21)(q22;q22.1); RUNX1::RUNXT1, inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB::MYH11 or t(15;17)(q24.1;q21.2); and PML::RARA, are categorized as AML regardless of whether the blast count meets the diagnostic criterion of 20% for AML [24,25].