From an analysis using a single-tube eight-color combination, including CD11b, CD13, CD33, CD34, CD45, CD64, CD117, and HLA-DR, a unique immune profile of the absence of CD34, HLA-DR, and CD11b was found to be the most specific for the diagnosis of APL, with better specificity (93.3%) and a positive predictive value (93.1%) and similar sensitivity (90%) compared with other antigen combinations [69]. This evidence concerns the gene CD33 and acute promyelocytic leukemia.