The leukemic blasts in AMKL are characterized by megakaryocytic differentiation and express high levels of megakaryocytic markers, including CD42a, CD41, CD61, and/or CD42b, with variable expression of CD4, CD7, CD33, CD34, CD36, CD38, CD56, and CD71 [119] (Figure 8). Here, ITGA2B is linked to acute megakaryoblastic leukemia.