In the proximal small intestine, the CPC;Apcfl/fl;Klk6+/+ and the CPC;Apcfl/fl;Klk6+/fl mice had a comparable number of adenomas (2.30 ± 2.67 and 1.67 ± 2.55, respectively), while remarkably no adenomas were observed in CPC;Apcfl/fl;Klk6fl/fl mice; Table 1 and Figure 5A (* p = 0.04, small intestine CPC;Apcfl/fl;Klk6+/+ versus CPC;Apcfl/fl;Klk6fl/fl). The gene discussed is KLK6; the disease is adenoma.