In contrast, the number of high-grade adenomas in the small intestine of CPC;Apcfl/fl;Klk6fl/fl mice (0.58 ± 0.80) was significantly lower than in CPC;Apcfl/fl;Klk6+/+ mice (1.7 ± 0.95) and CPC;Apcfl/fl;Klk6+/fl mice (1.71 ± 1.38) (p = 0.03 and p = 0.04, respectively). Here, KLK6 is linked to adenoma.