The pathology analysis revealed that CPC;Apcfl/fl;Klk6+/+, CPC;Apcfl/fl;Klk6+/fl, and CPC;Apcfl/fl;Klk6fl/fl mice had mild subacute multifocal colitis with mixed lymphocytic and neutrophilic infiltrates in the colon but not in the small intestine. Here, KLK6 is linked to colitis.