CCN2 and myeloid sarcoma: Apart from serotonin, many other mediators have been studied as potentially responsible for MS, such as Transforming Growth Factor-α and -β (TGF-α, TGF-β), Connective Tissue Growth Factor (CTGF), Platelet-Derived Growth Factor (PDGF), Insulin-Like Growth Factor 1 (IGF-1), and Epidermal Growth Factor (EGF) [54].