Importantly, in a subset of patients with CEA levels greater than 192 ng/mL, a PGE2 threshold of 0.5 pg/μL produced 78% sensitivity, 100% specificity, and 86% accuracy for the detection of HGD/invasive IPMN [78]. The gene discussed is CEACAM5; the disease is pancreatic intraductal papillary-mucinous neoplasm.