Notable examples include the MMTV-HER2 breast cancer model, the KrasLSL-G12D; p53flox/flox lung and pancreatic cancer model, and the Apc flox/flox; KrasLSL-G12D; p53flox/flox colon cancer model, which have been the focus of major studies [55]. Here, ERBB2 is linked to breast carcinoma.