For example, an elegant experiment in glioblastoma mouse models using a ganciclovir-induced ablation tool specific for the population of QCCs (Nestin-ΔTK-GFP) revealed that a small population of Nestin-positive quiescent glioma cells remains after chemotherapy and acts as propagating seeds for glioblastoma recurrence [14]. This evidence concerns the gene NES and central nervous system cancer.