These eight variants were either associated with potential hereditary tumor syndromes without any surveillance recommendations based on patient phenotype and pedigree (variants in the genes CHEK2, EXT1, ATM), or they were weakly associated with a condition potentially increasing the risk of cancer without being likely causative for a cancer syndrome in this specific case (variants in the genes MRE11, BRIP1, ATR, DDX41, MITF, SDHAF2). The gene discussed is DDX41; the disease is cancer.