TP53 and leiomyosarcoma: For example, heritable TP53-related cancer syndrome is associated with an increased risk of osteosarcomas and soft tissue sarcomas [5], and heritable retinoblastoma syndrome (with germline pathogenic variants in the RB1 gene) increases the risk of osteosarcomas, rhabdomyosarcomas, and leiomyosarcomas [6].