Three tumor markers for SCLC were measured in drug-sensitive H69 and drug-resistant VPA cells treated with EB and compared with untreated cells: neuron-specific enolase (NSE), caveolin-1 (CAV), and avian myelocytomatosis viral oncogene lung carcinoma-derived homolog (MYCL1). This evidence concerns the gene CAV1 and small cell lung carcinoma.