Furthermore, by combining observations of significant apoptotic effects seen in breast cancer cells exposed to Netupitant with the critical role of mTOR signaling in suppressing breast cancer cell apoptosis [35,36], this study elucidates the relationship between Netupitant, the PI3K/AKT/mTOR pathway, and apoptosis through both in vitro and in vivo experiments. Here, AKT1 is linked to breast carcinoma.