Among these gene signatures, we found that groups C (associated with tissue development and adhesion proteins) and E (associated with cell differentiation) were the top-ranked gene sets enriched in PRMT5KO and WDR77KO, respectively (Figure 2B), supporting the potential roles of PRMT5 and WDR77 in HNSCC-specific pathways. The gene discussed is WDR77; the disease is head and neck squamous cell carcinoma.