Gal-4 engages with C1GALT1-(glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1)-dependent O-glycans to promote metastasis and castration resistance (leading to the ineffectiveness of the androgen-deprivation therapy of PCa). Here, C1GALT1 is linked to posterior cortical atrophy.