UTY has the UTX homolog (also known as KDM6A) that encodes a demethylase of lysine 27 on histone 3 (H3K27), which is linked to dysregulated squamous cell differentiation in HNSCC cell lines: UTY could have the same function albeit with reduced activity [107,108]. Here, KDM6A is linked to head and neck squamous cell carcinoma.