ANXA2 and neoplasm: A study by Guzmán-Aránguez et al. in human colorectal adenocarcinoma (CAC) cell lines demonstrated that the dedifferentiation of CAC cells is associated with the up-regulation of ANXA2 and its subcellular relocation [83], while Tristante et al. found that a high number of ANXA2-positively labeled (membranous pattern of expression) in the tumor invasive front was associated with high invasiveness and lymph node metastasis of CRC [84].