Yonglitthipagon et al. demonstrated that ANXA2 is overexpressed in CCA tissues linked with Opisthorchis Viverrini infection, and that its high expression was associated with metastasis, lymphatic and perineural invasion, poor prognosis, and shorter survival time, but not with the histological subtype or the tumor size of CCA. Here, ANXA2 is linked to cholangiocarcinoma.