HAb18G/CD147 and WAVE2, as well as the DOCK3-β-catenin-WAVE2 and the Integrin-FAK-PI3K/PIP3 signaling pathways, are all closely linked to ANXA2 and the movement and metastasis of HCC cells, and could thus be exploited therapeutically [100,101]. The gene discussed is PTK2; the disease is hepatocellular carcinoma.