PTX3 and colorectal cancer: Notably, high expression levels of PTX3 protein in serum and tumor tissues have been associated with poor prognoses in various human malignancies, including colorectal cancer, diffuse large B cell lymphoma, hepatocellular carcinoma, glioma, ovarian cancer, pancreatic cancer, primary myelofibrosis, and small cell lung cancer [15,16,17,18,19,20,21,22,23].